Nodule

Varian will support my research project entitled “Longitudinal CBCT radiomics analysis for lung cancer radiotherapy response and prognosis prediction” with $230,000 over 2 years. This is the first research grant from Varian to the Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University. This project can potentially impact the clinical practice of lung cancer patients by using standard imaging modalities (CBCT and 4D-CBCT) to provide early prediction of prognosis and toxicity. ...

MICCAI'22 Paper | CMPB'21 Paper | CIRDataset This library serves as a one-stop solution for analyzing datasets using clinically-interpretable radiomics (CIR) in cancer imaging (https://github.com/choilab-jefferson/CIR). The primary motivation for this comes from our collaborators in radiology and radiation oncology inquiring about the importance of clinically-reported features in state-of-the-art deep learning malignancy/recurrence/treatment response prediction algorithms. Previous methods have performed such prediction tasks but without robust attribution to any clinically reported/actionable features (see extensive literature on the sensitivity of attribution methods to hyperparameters). This motivated us to curate datasets by annotating clinically-reported features at the voxel/vertex level on public datasets (using our published advanced mathematical algorithms) and relating these to prediction tasks (bypassing the “flaky” attribution schemes). With the release of these comprehensively-annotated datasets, we hope that previous malignancy prediction methods can also validate their explanations and provide clinically-actionable insights. We also provide strong end-to-end baselines for extracting these hard-to-compute clinically-reported features and using these in different prediction tasks. ...

A comprehensive framework for lung cancer screening radiomics using LIDC-IDRI and LUNGx dataset. Data preprocessing - download data, conversion, etc. Radiomics feature extraction including spiculation features AutoML model building and validation Source code https://github.com/choilab-jefferson/LungCancerScreeningRadiomics Publications Wookjin Choi, Jung Hun Oh, Sadegh Riyahi, Chia-Ju Liu, Feng Jiang, Wengen Chen, Charles White, Andreas Rimner, James G. Mechalakos, Joseph O. Deasy, and Wei Lu, “Radiomics analysis of pulmonary nodules in low-dose CT for early detection of lung cancer”, Medical Physics, Vol. 45, No. 4, pp. 1537-1549, April 2018. https://doi.org/10.1002/mp.12820 Wookjin Choi, Saad Nadeem, Sadegh Riyahi, Joseph O. Deasy, Allen Tannenbaum, Wei Lu, “Reproducible and Interpretable Spiculation Quantification for Lung Cancer Screening.” Computer methods and programs in biomedicine. 200 2021. https://doi.org/10.1016/j.cmpb.2020.105839

Choi, W., Nadeem, S., Alam, S. R., Deasy, J. O., Tannenbaum, A., & Lu, W. (2020). Reproducible and Interpretable Spiculation Quantification for Lung Cancer Screening. Computer Methods and Programs in Biomedicine, 105839. https://doi.org/10.1016/j.cmpb.2020.105839 Source codes: https://github.com/choilab-jefferson/LungCancerScreeningRadiomics Highlights A novel interpretable spiculation feature is presented, computed using the area distortion metric from spherical conformal (angle-preserving) parameterization. A simple one-step feature and prediction model is introduced which only uses our interpretable features (size, spiculation, lobulation, vessel/wall attachment) and has the added advantage of using weak-labeled training data. ...

UKC2018 Aug 4, 2018 MSKCC Postdoctoral Research Symposium Sep 28, 2018 https://twitter.com/arxiv_org/status/1034746650089021445 Presented at MICCAI ShapeMI Workshop https://shapemi.github.io/program/

KOCSEA Technical Symposium 2017, Invited Talk, KSEA Travel Grant